Causes of Ovarian Cancer

There are many theories about the causes of ovarian cancer. Some of them came from looking at the things that change the risk of ovarian cancer. For example, pregnancy and taking birth control pills both lower the risk of ovarian cancer. Since both of these things reduce the number of times the ovary releases an egg (ovulation), some researchers think that there may be some relationship between ovulation and the risk of developing ovarian cancer.
Also, we know that tubal ligation and hysterectomy decrease the risk of ovarian cancer. One theory to explain this is that some cancer-causing substances may enter the body through the vagina and pass through the uterus and fallopian tubes to reach the ovaries. This would explain the effect of removing the uterus or blocking the fallopian tubes on ovarian cancer risk. Another theory is that male hormones (androgens) can cause ovarian cancer.
Researchers have made great progress in understanding how certain mutations (changes) in DNA can cause normal cells to become cancerous. DNA is the chemical that carries the instructions for nearly everything our cells do. We usually resemble our parents because they are the source of our DNA. However, DNA affects more than our outward appearance. Some genes (parts of our DNA) contain instructions for controlling when our cells grow and divide. Certain genes that promote cell division are called oncogenes. Others that slow down cell division, cause cells to die at the appropriate time, or help repair DNA damage are called tumor suppressor genes. We know that DNA mutations (defects) that turn on oncogenes or turn off tumor suppressor genes can cause cancer.

BRCA1 and BRCA2 genes

Although inherited mutations in these genes were first found in women with breast cancer, they are also responsible for most inherited ovarian cancers. When these genes are normal, they act as tumor suppressors — they help to prevent cancer by making proteins that keep cells from growing abnormally. But if you have inherited a mutation (defect) of one of these genes from either parent, this cancer-preventing protein is less effective, and your chances of developing breast and/or ovarian cancer increase. Mutations in BRCA1 and BRCA2 are about 10 times more common in those who are Ashkenazi Jewish than those in the general U.S. population.
The lifetime ovarian cancer risk for women with a BRCA1 mutation is estimated to be between 35% and 70%. This means that if 100 women had the BRCA1 mutation, between 35 and 70 of them would get ovarian cancer. For women with BRCA2 mutations the risk has been estimated to be between 10% and 30% by age 70. These mutations also increase the risks for primary peritoneal carcinoma and fallopian tube carcinoma.
In comparison, the ovarian cancer lifetime risk for the women in the general population is about 1.5%.

Cowden’s disease

In this syndrome, people are primarily affected with thyroid problems, thyroid cancer, and breast cancer. Women also have an increased risk of ovarian cancer. It is caused by inherited mutations in the PTEN gene.

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